![]() ![]() A total of 597 bioactive-related targets and 4245 cancer-related targets were identified from public databases. GC-MS detected a total of 34 bioactives and all were accepted by Lipinski’s rules and therefore classified as drug-like compounds (DLCs). Finally, we implemented a molecular docking test (MDT) to explore key target(s) and compound(s) on AutoDockVina and LigPlot+. The networks between overlapping targets and bioactives were visualized, constructed, and analyzed by RPackage. Next, target(s) associated with the obtained bioactives or cancer-related targets were retrieved by public databases, and the Venn diagram selected the overlapping targets. maackii flower were revealed by gas chromatography-mass spectrum (GC-MS), and SwissADME evaluated their physicochemical properties. ![]() maackii flower against cancer via network pharmacology. This study identified the main compounds(s) and mechanism(s) of the C. or Korean thistle flower is a herbal plant used to treat tumors in Korean folk remedies, but its essential bioactives and pharmacological mechanisms against cancer have remained unexplored. ![]()
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